Spatial and temporal distribution of nitric oxide synthase (NOS) isoforms in the developing ovine kidney
Bibliographic record
Abstract
Previously we showed that NOS isoforms display an age dependent pattern of expression in the ovine kidney. The present study was designed to further elucidate intrarenal spatial and temporal localization of NOS isoforms in the developing ovine kidney. The in situ hybridization technique was utilized to localize mRNA of all three NOS isoforms (I‐III) in sheep aged: ~1 day, 1, 3, 6, and 12 weeks post natally (N=3). Constitutive isoforms (NOS I and III) were expressed at 1 day to 3 weeks in both the cortex and medulla, with decreased overall expression at 6 and 12 weeks. NOS I showed more intense signal within the cortex than the medulla at all ages. The inducible NOS isoform (NOS II) had less abundant expression than the constitutive isoforms at all ages. NOS I appeared greatest at 1 week, staining the glomeruli intensely, with a decrease after 3 weeks. By demonstrating NOS isoform transcripts to be more abundant in the early post natal period, these findings provide insight into the age dependent role of NO in modulating renal haemodynamics and function during ontogeny. Supported by the University Research Grant Committee and the Canadian Institutes of Health Research.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".