The role of MMP2 in persistent inflammation in Chronic Obstructive Pulmonary Disease (COPD)
Bibliographic record
Abstract
Rationale MMP2 modifies chemokines in ways that allow them to continue to bind to their receptors but fail to activate them (Science. 2000, 289:1202‐6). Objective To investigate the role of MMP2 expression and activity in the development of the persistent inflammatory process associated with progression of COPD. Methods The expression of MMP2 was measured by Taqman quantitative PCR in 136 paired samples of small bronchioles and surrounding lung tissue separated by laser capture microdissection from 63 patients in all 4 categories of COPD severity. MMP2 mRNA expression was compared to forced expiratory volume in one second (FEV 1 ) by linear regression analysis. As well, MMP2 activity was measured in 11 of these COPD patients' lungs by gelatin zymography. Results MMP2 expression and activity decreased in both the small airways and surrounding lung tissue with disease progression in COPD. Conclusions This sharp reduction of MMP2 expression and activity may contribute to the persistence of the inflammatory process in COPD by reducing the proteolytic modification of chemokines that normally blocks chemokine receptors to reduce the inflammatory response. Supported by grants NIH‐HL‐P50 084922 and CIHR MOP‐82815
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".