Maternal intake of vitamin B6 and maternal and cord plasma levels of pyridoxal 5' phosphate in a cohort of Canadian pregnant women and newborn infants
Bibliographic record
Abstract
Vitamin B6 is important in fetal development as an essential coenzyme involved in 1‐carbon metabolism. However, maternal intake and blood levels of B6 during pregnancy have not been well established. We determined dietary and supplemental B6 intakes from 368 Canadian pregnant women using a FFQ and measured pyridoxal 5' phosphate (PLP) levels in their plasma at baseline (11‐16 wks gestation), delivery and in umbilical cord plasma. Mean dietary B6 intake(95% CI) at baseline and delivery were 1.6(1.5‐1.7) and 1.6(1.5‐1.6) mg, respectively. 88% reported B6 supplement use during pregnancy; 75% met the RDA (1.9 mg) for B6 through supplement use. Geometric mean (95%CI) PLP levels were 110(101‐119), 61(56‐65), and 297(277‐319) nmol/L at baseline, delivery and in cord blood, respectively (p<0.0001). 11 and 24% of pregnant women had suboptimal PLP levels (<20 nmol/L) at baseline and delivery, respectively. 58% of the women with suboptimal PLP had B6 intake of at least the RDA. Maternal PLP levels from supplement users were higher than those from nonusers at baseline (p=0.001) but not at delivery (p=0.47). Cord PLP levels from users were higher than those from nonusers (p=0.005). Although 75% of the women met the RDA for B6 mostly through supplements, 11‐24% had suboptimal plasma PLP levels. B6 supplementation may not be sufficient for adequate maternal PLP levels during pregnancy. Future studies are warranted to determine optimal B6 intake and blood levels during pregnancy. Funded by: CIHR (MOP#106446)
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".