Strain‐Dependence in Susceptibility to Heart Failure: Role of Mitochondria
Bibliographic record
Abstract
The purpose of this study was to compare two genetically different strains of rats submitted to overload‐induced ventricular remodelling to examine factors that predispose to the progression toward heart failure. Volume overload was induced by an aorto‐caval fistula (ACF) in SD and WKHA male rats, and hearts were studied at 4, 8 and 12 weeks after surgery. Compared to WKHA, ACF‐induced LV hypertrophy and dysfunction progressed more rapidly in SD rats, and functional recovery of SD hearts to I‐R was poorer vs WKHA during the compensated phase of disease. At later times (up to 40 weeks after ACF), SD rats (but not WKHA rats) died progressively of acute cardiac decompensation. Both strains developped a vulnerability to opening of the PTP, as measured in situ (in ischemic‐reperfused hearts using the mitochondrial [ 3 H]DOG entrapment method) or in isolated mitochondria submitted to in vitro stress. Increased vulnerability to PTP opening was observable beginning at 4 weeks but no differences in severity was apparent between strains. The % of collagen‐cross linking increased progressively after ACF in both strains, but to a lower extent in SD vs. WKHA hearts. These results suggest that, while mitochondrial dysfunction may participate to the negative consequences of ACF‐induced LVH in both strains, it is not responsible for the more the rapid progression to decompensation observed in SD rats. Further experiments are underway to test the differences in cardiac outcome may be due to differences in the levels of collagen‐cross linking. Funded by: CIHR, FRSQ
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".