The Palatability and Comparative Efficacy of Meloxicam Oral Suspension for the Treatment of Chronic Musculoskeletal Disease in Horses
Why this work is in the frame
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Bibliographic record
Abstract
The objective of the study was to evaluate the efficacy and ease of treatment of an oral meloxicam suspension for the treatment of chronic musculoskeletal lameness in horses. A crossover palatability study consisting of 30 healthy horses and ponies was conducted to compare the time to consume a 400-gram meal of oats alone to a 400-gram meal of oats top dressed with meloxicam oral suspension (MOS) (0.6 mg/kg body weight [BW]). The mean time to consume a 400-gram meal of oats only was 301.0 ± 145 seconds and was 286.3 ± 125.6 seconds for MOS. There was no difference between the consumption duration times of oats with or without MOS. Horses (77) were enrolled into a blinded, active-controlled, randomized clinical study. Treatment 1 consisted of animals receiving MOS (0.6 mg/kg BW q24 hours for 5 days), and treatment 2 consisted of animals receiving phenylbutazone paste (1 g/454 kg BW, q12 hours for 5 days). Animals were treated on day 0 and evaluated for lameness associated with of musculoskeletal disease on day 5. For both treatments 1 and 2, the day 5 lameness scores were significantly less than the day 0 lameness scores. At a walk and trot, there were no differences in efficacy between phenylbutazone and MOS (based on absolute score values, differences in scores between day 0 and day 5, and proportion of horses responding to treatment). It was concluded that MOS was palatable and effective for the treatment of musculoskeletal disease.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.003 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it