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Record W2295062809

Человек в экстремальных условиях Арктики

2010· article· ru· W2295062809 on OpenAlexaboutno aff
Панин Лев Евгеньевич

Bibliographic record

VenueСибирский научный медицинский журнал · 2010
Typearticle
Languageru
FieldBiochemistry, Genetics and Molecular Biology
TopicHigh Altitude and Hypoxia
Canadian institutionsnot available
Fundersnot available
KeywordsChemistryLipid peroxidationMicroviscosityLipid metabolismVery low-density lipoproteinEndocrinologyBiochemistryInternal medicineCholesterolLipoproteinFood scienceMembraneBiologyOxidative stress
DOInot available

Abstract

fetched live from OpenAlex

The participants of trans-ski transition «Russia North pole Canada» on the drifting ice during the polar day were examined. The group included 13 people: 9 Russian, and 4 Canadian sportsmen. The transition took place in an autonomous mode. Length of the rout was 1734 km. Average load about 40 kg/person. The results showed that physical activity in the Arctic leads to increased production and content of glucocorticoids and catecholamines in the blood in normal or reduced content of insulin. This determines the shift of carbohydrate type of energy metabolism on the lipid type. The content of triglycerides, total cholesterol and VLDL fractions in the blood was decreased. The shift of lipoprotein spectrum in the direction of increasing HDL was observed. Enhanced lipid metabolism increased the request for tissue O2 consumption. The structural changes in erythrocyte membranes associated with a decrease in content of tocopherol and increased contents of lipid peroxidation products (diene conjugates) and lizoform phospholipids, promoting the formation of protein-lipid crosslinks were revealed. Capillary viscosimetry showed an increase in the viscosity of erythrocyte membranes in the end of the path, which is probably due to the accumulation of above noted changes. It was shown in the experimental conditions that stress hormones (Cortisol) interact with erythrocytes, increasing the microviscosity of their membranes both in the field of lipid-lipid and protein-lipid interactions. It is suggested that in extreme Arctic conditions, these changes contribute to the development of tissue hypoxia and reduced physical performance.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.124
Threshold uncertainty score0.247

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0070.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.241
Teacher spread0.234 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2010
Admission routes1
Has abstractyes

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