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Inhibitory Effects of Ginseng (Panax ginseng) Berry on Tumour Promotion and Inflammatory Ear Oedema Induced by TPA

2016· article· en· W2298100396 on OpenAlexvenueno aff
Ken Yasukawa, Wan Kyunn Whang, Sung-Kwon Ko

Bibliographic record

VenueJournal of Nutritional Therapeutics · 2016
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGinseng Biological Effects and Applications
Canadian institutionsnot available
FundersMinistry of Agriculture, Food and Rural Affairs
KeywordsGinsengPharmacologyProtopanaxadiolInflammationChemistryTraditional medicineAraliaceaeTumor promotionCarcinogenesisMedicineCancerGinsenosideInternal medicinePathology

Abstract

fetched live from OpenAlex

Background: Occult hepatitis B infection (OHBI), defined as positive seroreactivity for HBV DNA and negative seroreactivity for hepatitis B surface antigen (HBsAg), poses a challenge due to its hidden and asymptomatic nature. This study aimed to investigate the molecular rate of OHBI in blood donors and to assess the accompanying liver function profile.Methods: Blood specimens from 200 HBsAg-negative blood donors were tested by a rapid chromatographic assay (Micro-point combo kit, USA) for HBV serological markers (HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb) and detection of HBV DNA by nested PCR.Results: Of the 200 HBsAg-negative donors, 160 (80%) were seronegative for any hepatitis B serologic marker. Conversely, 5 (2.5%) HBsAb+, 4 (2%) HBcAb+, 11 (5.5%) HBsAb+HBcAb+, 20 (10%) HBcAb+HBeAb+ were positive. Of significance, 4 (2%) donors had evidence of HBV DNA, corresponding to a 2% OHBI prevalence in this population. Moreover, OHBI-positive donors presented higher levels of liver enzymes indicative of potential liver injury. OHBI was detected in 2% of blood donors, showing the risk of HBV transmissibility by blood transfusion from those who are seemingly negative for HBsAg. In addition, the high liver enzymes in OHBI-positive donors may signify a link with the outcome of chronic HBV infection.Conclusions: Our data suggest the need to develop a sensitive screening strategy to identify OHBI among blood donors in order to reduce HBV transmission. It also highlights the importance of monitoring liver function tests in OHBI-positive individuals to prevent possible liver-related complications sequelae.Keywords:Blood donors, Blood transfusion, Liver function, Occult hepatitis B infection

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.043
Threshold uncertainty score0.370

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.257
Teacher spread0.241 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2016
Admission routes1
Has abstractyes

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