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Record W2301504663 · doi:10.1039/c5sc04252f

An enzyme-activatable and cell-permeable Mn<sup>III</sup>-porphyrin as a highly efficient <i>T</i><sub>1</sub> MRI contrast agent for cell labeling

2016· article· en· W2301504663 on OpenAlexafffund
Inga E. Haedicke, Tan Li, Yong Zhu, Francisco M. Martínez, Amanda M. Hamilton, Donna H. Murrell, Joris Nofiele, Hai‐Ling Margaret Cheng, Timothy J. Scholl, Paula J. Foster, Xiaoan Zhang

Bibliographic record

VenueChemical Science · 2016
Typearticle
Languageen
FieldMaterials Science
TopicLanthanide and Transition Metal Complexes
Canadian institutionsTed Rogers Centre for Heart ResearchWestern UniversityHospital for Sick ChildrenThe Scarborough HospitalSickKids FoundationUniversity of TorontoRobarts Clinical TrialsToronto Public Health
FundersNatural Sciences and Engineering Research Council of CanadaHospital for Sick ChildrenUniversity of TorontoCanada Foundation for InnovationUniversity of Toronto ScarboroughOntario Institute for Cancer ResearchSick Kids FoundationHeart and Stroke Foundation of Canada
KeywordsPorphyrinContrast (vision)ChemistryNuclear magnetic resonanceCellMRI contrast agentCrystallographyCombinatorial chemistryGadoliniumPhysicsPhotochemistryBiochemistryOrganic chemistryOptics

Abstract

fetched live from OpenAlex

MnAMP, a cell-trappable pro-contrast agent gets enzymatically activated and accumulated intracellularly to provide a strong MRI signal for cell labeling.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.737

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.228
Teacher spread0.216 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations35
Published2016
Admission routes2
Has abstractyes

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