Effect Of Exercise In Plasma Cytokines And Soluble Receptors Levels In Elderly Women With Osteoarthritis
Bibliographic record
Abstract
Osteoarthritis (OA) is a common disease in the elderly population worldwide that mostly affects the knee. Studies have demonstrated that the production of inflammatory mediators increases when joints are exposed to greater shear forces and overload, resulting in greater joint wear, as in OA. Exercise has been proposed as a non-pharmacological intervention to alleviate and treat OA, but its effects are not well understood. PURPOSE: To investigate and correlate plasma levels of interleukin six (IL-6), tumor necrosis factor alpha (TNF-α) and the soluble form of TNF-α receptors (sTNFR1 and sTNFR2) in elderly individuals with knee OA to pain, stiffness and functionality. METHODS: Before and after an aerobic training program (walking, 3 times/week, 12 weeks) volunteers (n=15, 67±4 years) performed an acute exercise and blood samples were collected before, immediately after and 30 minutes after acute exercise. Clinical and functional assessments were also conducted before and after training (the Western Ontario and McMaster Universities Osteoarthritis Index - WOMAC- questionnaire and the 6-minute walk test -TC6min). The plasma concentrations of the soluble receptors and cytokines were measured by ELISA. Data were analyzed using the factorial ANOVA with split plot (2 × 3) with Bonferroni post hoc, considering a significance level of 5%. RESULTS: The levels of sTNFR-1 were increased (540±289 pg/ml to 1120±209 pg/ml) while sTNFR-2 levels were reduced (4543±1688 pg/ml to 3178±1050 pg/ml) after training. There was an inverse correlation between the levels of sTNFR-1 and the WOMAC domains of physical function (r=-0.51; p=0.034) and a direct correlation with TC6min (r=0.62; p=0.010). There was no significant change in plasma IL-6 and TNF-α levels after acute or chronic exercise. CONCLUSION: sTNFR-1 levels were reduced while sTNFR-2 levels were increased by aerobic training of OA patients. Alterations of sTNFR-1 levels were correlated to clinical improvement pointing to the participation of the inflammatory response in the clinical outcome of OA. Support by: CNPq, CAPES, FAPEMIG, Brazil.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".