Structural and mutational studies of anthocyanin malonyltransferases
Bibliographic record
Abstract
4 4 is a key player in the formation of large complexes on gene promoters leading to chromatin remodelling and gene activation. CARM1 has now been shown to methylate a large variety of proteins which are all vital to gene expression. CARM1 contains 608 amino acids in human and its architecture has been schematically divided into three domains. CARM1 is built around a catalytic core domain that is well conserved in sequence (and therefore in structure) among all PRMTs members. CARM1 possesses two unique additional domains attached, respectively, at the NH2-terminal and at the COOH-terminal end of the PRMT active site. Both NH2-terminal domain and COOHterminal domain have been shown to be required for the coactivator function of human CARM1. We have solved six crystal structures corresponding to three isolated modules of CARM1. Five crystal structures of the CARM1 catalytic module, two free, two cofactor and one inhibitor bound forms have revealed large structural modifications and shown that the NH2-terminal and the COOHterminal end of CARM1 catalytic module contain molecular switches that may inspire how CARM1 regulates its biological activities by protein-protein interactions. Full detailed analysis of the structures will be presented.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".