Inducing remission with nutritional therapy has better height gain in comparison to corticosteroid in children with Crohnʼs disease
Bibliographic record
Abstract
Several studies have reported nutritional therapy to have an equivalent efficacy in achieving remission in Crohn's disease (CD) when compared with corticosteroids. However, the effect of these treatments on changing height and weight has not been reported in the pediatric population. In this retrospective chart review we aim to compare the efficacy of nutritional therapy with corticosteroid therapy in inducing clinical remission; as well as, the effect on nutritional status (% weight gain and δ height z-scores) within one year of diagnosis of CD. Pediatric Crohn's disease patients diagnosed from the last 7 years had clinical, laboratory, demographic and endoscopic data collected. Forty-four patients received corticosteroids (mean age 11.46 years) and 13 received nutritional therapy (mean age 12.93 years). Both nutritional therapy and corticosteroids had equivalent PCDAI score at the time of diagnosis. Both achieved a similar remission rate within the one year time frame. 84.6% of nutritional therapy patients compared to 86.4% of corticosteroid patients. The relapse rate was also similar with nutritional therapy at 38.5% and corticosteroids at 29.5%. Nutritional status was shown not to be significantly different in terms of weight gain; nutritional therapy patients showed a mean weight gain of 22.162%, while steroid patients had a mean of 23.315%. However, change in height z-scores were shown to be significantly different with nutritional therapy patients giving a mean change of 0.098, while corticosteroid patients had a mean change of -.127, (p<0.05). It appears that the efficacy of the two therapies is similar in terms of remission rates. Weight gain appears to be similar in both groups, while change in height z-scores was significantly greater in those patients receiving nutritional therapy, making nutritional therapy an ideal agent in inducing remission in children with Crohn's disease.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".