Binding of Sodium Cholate In Vitro by Cationic Microfibrillated Cellulose
Bibliographic record
Abstract
In this work, a series of cationic microfibrillated cellulose (CMFC) were prepared by introducing quaternary amine groups, and the sorption of a model compound for bile salts, sodium cholate, in vitro was determined. Various variables, contact time, initial concentration of sodium cholate, and the presence of salts, were investigated. Experimental results showed that the in vitro binding of sodium cholate of the CMFC was 57.95 mg/g, which was about 70% lower than that of cholestyramine. The isotherm data were analyzed according to Langmuir, Freundlich, and Tempkin models. Characteristic parameters of each model were determined. Results also showed that the Langmuir isotherm performed the best correlation for the sorption of sodium cholate onto the CMFC, and the maximum capacity, Q max was 416.67 mg of sodium cholate per gram of CMFC. The sorption kinetics underwent a pseudo-second-order equation, suggesting a chemisorptions mechanism. Additionally, the presence of salts in the reaction system greatly prevented the CMFC sorption toward cholate, implying the interaction between sodium cholate and CMFC was electrostatic in nature. All these results support the great potential for using the CMFC as a sorbent to decrease cholesterol.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".