Mechanistic Investigation of the Hydrogenation of Ketones Catalyzed by a Ruthenium(II) Complex Featuring an N-Heterocyclic Carbene with a Tethered Primary Amine Donor: Evidence for an Inner Sphere Mechanism

The complex [Ru( p -cymene)( m -CH 2 NH 2 )Cl]PF 6 ( 1 ) catalyzes the H 2 -hydrogenation of ketones in basic THF under 25 bar of H 2 at 50 °C with a turnover frequency (TOF) of up to 461 h −1 and a maximum conversion of 99%. When the substrate is acetophenone, the TOF decreases significantly as the catalyst to substrate ratio is increased. The rate law was then determined to be rate = k H [Ru] tot [H 2 ]/(1 + K eq [ketone]), and [ 1 ] is equal to [Ru] tot if catalyst decomposition does not occur. This is consistent with the heterolytic splitting of dihydrogen at the active ruthenium species as the rate-determining step. In competition with this reaction is the reversible addition of acetophenone to the active species to give an enolate complex. The transfer to the ketone of a hydride and proton equivalent that are produced in the heterolytic splitting reaction yields the product in a fast, low activation barrier step. The kinetic isotope effect was measured using D 2 gas and acetophenone- d 3, and this gave values ( k H / k D ) of 1.33 ± 0.15 and 1.29 ± 0.15, respectively. The ruthenium hydride complex [Ru( p -cymene)( m -CH 2 NH 2 )H]PF 6 ( 2 ) was prepared, as this was postulated to be a crucial intermediate in the outer-sphere bifunctional mechanism. This is inactive under catalytic conditions unless it is activated by a base. DFT computations suggest that the energy barriers for the addition of dihydrogen, heterolytic splitting of dihydrogen, and concerted transfer of H + /H − to the ketone for the outer-sphere mechanism would be respectively 18.0, 0.2, and 33.5 kcal/mol uphill at 298 K and 1 atm. On the other hand, the energy barriers for an inner-sphere mechanism involving the decoordination of the amine group of the NHC ligand, the heterolytic splitting of dihydrogen across a Ru−O(alkoxide) bond, and hydride migration to the coordinated ketone, are respectively 15.5, 17.5, and 15.6 kcal/mol uphill at 298 K and 1 atm. This is more consistent with the experimental observation that the heterolytic splitting of dihydrogen is the turnover-limiting step. This was confirmed by showing that an analogous complex with a tethered teritiary amine group has comparable activity for the H 2 -hydrogenation of acetophenone. The related complex [Os( p -cymene)( m -CH 2 NH 2 )Cl]PF 6 ( 6 ) was synthesized by a transmetalation reaction with [Ni( m -CH 2 NH 2 ) 2 ](PF 6 ) 2 ( 5 ) and [Os( p -cymene)Cl 2 ] 2, and its catalytic activity toward hydrogenation of acetophenone was also investigated.

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