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Record W2316749091 · doi:10.1017/s0317167100005047

Optic Nerve Enlargement Associated with Globoid Cell Leukodystrophy

2006· article· en· W2316749091 on OpenAlexaffvenue
Miguel Bussière, Richard Farb, Trevor Kotylak, Kusuma Naik, Simon A. Levin

Bibliographic record

VenueCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · 2006
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRetinoids in leukemia and cellular processes
Canadian institutionsWestern University
Fundersnot available
KeywordsLeukodystrophyNeuroscienceMedicineAnatomyPathologyBiologyDisease

Abstract

fetched live from OpenAlex

A six-month-old female developed marked irritability, multifocal myoclonic jerks and episodic opisthotonus. Developmental milestones and growth (height and weight) plateaued at three months of age, despite adequate oral intake. Pregnancy, birth and family history were non-contributory. Neurological examination revealed a very irritable baby with poor visual contact and tracking. Head circumference was in the 7th percentile and height and weight were less than the 2nd percentile for age and gender. Funduscopic examination was unremarkable. Appendicular and truncal tone were increased, deep tendon reflexes were difficult to elicit and plantar responses were downgoing. Hands were tightly fisted. There was no significant dysmorphism, skin lesion or organomegaly.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesScience and technology studies
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.726
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0020.004
Scholarly communication0.0010.000
Open science0.0020.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.217
Teacher spread0.206 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations12
Published2006
Admission routes2
Has abstractyes

Explore more

Same venueCanadian Journal of Neurological Sciences / Journal Canadien des Sciences NeurologiquesSame topicRetinoids in leukemia and cellular processesFrench-language works237,207