1074 DISCORDANCE IN CIRCULATING VON WILLEBRAND FACTOR AND SEXUAL DYSFUNCTION BETWEEN MEN AND WOMEN WHO ARE OVERWEIGHT/OBESE
Bibliographic record
Abstract
Introduction: There is an established link between sexual dysfunction (SD) and CVD in men, sharing similar etiologies including endothelial dysfunction. This association has not been well characterized in women. Our study evaluated circulating Von Willebrand Factor (VWF), a biomarker of endothelial function and its association with SD in men and women. Methods: A cross-sectional analysis of overweight and obese men (N = 19, 34-67yrs) and women (N = 29, 35-64yrs) was performed. Male sexual function was determined via IIEF questionnaires (scores ≤25 reflect SD). Females received FSFI questionnaires (scores ≤26 reflect SD). BMI, waist circumference and circulating osteoprotegerin (OPG), C reactive protein (CRP), VWF propeptide (VWFpp) and VWF antigen (VWF:Ag) were measured. Results: Biometrics were similar between SD and normal individuals. In males with SD there was a significant increase in VWF:Ag and VWFpp. In contrast, in women with SD the levels of VWFpp were significantly lower. There were no differences in other biomarkers.Mean ± SD Conclusions: Increased circulating VWF, but not OPG or CRP, is associated with SD in overweight/obese men. Whether endothelial dysfunction precedes inflammatory changes associated with SD in men remains to be determined. Conversely, in women with SD the levels of VWFpp were decreased. Although the concept has been contentious, these findings suggest that vascular mechanisms may not be as important in the etiology of SD in women. (Funds:H&SC, CIHR, MTM:CIHR-DRA CP:Queen's Dept.Med-PDF)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".