Bibliographic record
Abstract
Familial Mediterranean fever (FMF) is a hereditary periodic fever disease that presents with recurrent attacks of peritonitis, pleuritis, arthritis, or erysipelas-like erythema1. The attacks last up to 3 days, with varying degrees of frequency. One of the most devastating complications of the disease is amyloidosis, which primarily affects the kidneys but can involve the liver, intestines, and the heart. Colchicine is the drug of choice for FMF2,3. It controls acute attacks of FMF and fends off development of amyloidosis. Since the introduction of colchicine for treatment of FMF, amyloidosis is infrequently seen among compliant patients. In the past, the mere presence of proteinuria in a patient with FMF suggested a diagnosis of renal amyloidosis since it was the most common kidney involvement in this disease. Nevertheless, more than 30 years ago, Eliakim, et al already reported that patients with FMF could have renal diseases other than amyloidosis4. Among these are hemorrhagic glomerulonephritis, chronic glomerulonephritis, Henoch-Schönlein nephritis, and polyarteritis nodosa (PAN). In another report in which Eliakim, et al studied 106 FMF patients, amyloidosis was found in only 13 of 19 patients with persistent albuminuria5. Renal biopsies in 4 of the 6 cases without amyloidosis showed minimal nondiagnostic changes, focal glomerulonephritis, or segmental glomerular sclerosis. Both studies were published prior to the introduction of colchicine treatment. More recently, Said, et al reported kidney biopsy pathologies in 15 patients with FMF and proteinuria6. Thirteen had urine protein of more than 1 g/24 h. Only 7 had amyloidosis, while 6 had mesangial proliferative glomerulonephritis (with IgA or IgM deposition), and 2 had rapidly progressive glomerulonephritis. Most of the patients were noncompliant for colchicine. Owing to the high efficacy of colchicine treatment in preventing amyloidosis and to the possible existence of other … Address correspondence to Dr. Ben-Chetrit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, POB 12000. E-mail: eldad{at}hadassah.org.il
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".