Effect of Saline on Transitions in Poly(ethylene glycol)-Grafted Succinyl-Phosphoethanolamine Monolayers Bearing C<sub>16</sub>Aliphatic Chains
Bibliographic record
Abstract
To investigate the effect of saline on miscibility, phase, and conformational transitions in binary mixtures of a succinyl-phosphoethanolamine bearing C(16) aliphatic chains, DPPE-succinyl, and a poly(ethylene glycol) (PEG)-phospholipid conjugate with a PEG molecular weight of 2000, DPPE-PEG2000, we have compared the properties of monolayers spread on water and on phosphate buffered saline (PBS). A comparative analysis of monolayer surface pressure, surface potential, compressibility, and epifluorescence microscopy data has revealed that spreading on PBS induces unfavorable interactions between the two phospholipids, which stabilizes immiscible phases in mixed monolayers. Strikingly, the conformational transition in grafted PEG2000 chains on PBS could not be easily described by the existing interpretive schemes. Plausibly, this transition becomes partially impaired due to interactions with PBS. Thus, saline has a significant effect on miscibility, phase, and conformational transitions in these PEG-grafted monolayers bearing C(16) aliphatic chains, which may have implications for understanding the behavior of PEG-grafted phospholipid surfaces in aqueous media of biological relevance.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".