P-064 Impact of High Dose Vitamin D3 Supplementation in Treatment of Crohnʼs Disease in Remission
Bibliographic record
Abstract
Vitamin D deficiency has been implicated in the pathogenesis of Crohn's disease (CD) and vitamin D supplementation may have a role in the management of CD. The aim of this study was to assess the tolerability and efficacy of high dose vitamin D3 in patients with CD. This was a randomized, double-blind placebo-controlled trial of high dose vitamin D3 at 10,000 IU daily (n = 18) compared to low dose at 1000 IU daily (n = 16) in patients with CD in remission. The primary outcome was improvement in serum 25-hydroxy-vitamin D levels. High dose vitamin D3 at 10,000 IU daily significantly improved 25-hydroxy-vitamin D levels from a mean of 73.5 nmol/L (standard deviation [SD] 11.7 nmol/L) to 160.8 nmol/L (SD 43.2 nmol/L) (P = 0.02). In per-protocol analysis, a lower rate of clinical relapse of Crohn's disease was observed in patients receiving a high dose (0/12 or 0%) compared to those receiving a low dose of 1000 IU daily (3/8 or 37.5%) (P = 0.049). Significant improvements in depression and a good safety profile were observed in both groups treated with vitamin D3. Oral supplementation with high dose vitamin D3 at 10,000 IU daily significantly improved serum 25-hydroxy-vitamin D levels and led to lower rates of clinical relapse. Larger studies using high dose vitamin D3 for treatment of inflammatory bowel diseases are warranted.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".