P-064 Impact of High Dose Vitamin D3 Supplementation in Treatment of Crohnʼs Disease in Remission
Why this work is in the frame
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Bibliographic record
Abstract
Vitamin D deficiency has been implicated in the pathogenesis of Crohn's disease (CD) and vitamin D supplementation may have a role in the management of CD. The aim of this study was to assess the tolerability and efficacy of high dose vitamin D3 in patients with CD. This was a randomized, double-blind placebo-controlled trial of high dose vitamin D3 at 10,000 IU daily (n = 18) compared to low dose at 1000 IU daily (n = 16) in patients with CD in remission. The primary outcome was improvement in serum 25-hydroxy-vitamin D levels. High dose vitamin D3 at 10,000 IU daily significantly improved 25-hydroxy-vitamin D levels from a mean of 73.5 nmol/L (standard deviation [SD] 11.7 nmol/L) to 160.8 nmol/L (SD 43.2 nmol/L) (P = 0.02). In per-protocol analysis, a lower rate of clinical relapse of Crohn's disease was observed in patients receiving a high dose (0/12 or 0%) compared to those receiving a low dose of 1000 IU daily (3/8 or 37.5%) (P = 0.049). Significant improvements in depression and a good safety profile were observed in both groups treated with vitamin D3. Oral supplementation with high dose vitamin D3 at 10,000 IU daily significantly improved serum 25-hydroxy-vitamin D levels and led to lower rates of clinical relapse. Larger studies using high dose vitamin D3 for treatment of inflammatory bowel diseases are warranted.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it