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Record W2322853806 · doi:10.1021/om500911f

Hydroalumination of Alkenes and Alkynes by Primary Aluminum Hydrides under Mild Conditions

2014· article· en· W2322853806 on OpenAlexafffund
James C. Fettinger, Paul A. Gray, Christopher E. Melton, Philip P. Power

Bibliographic record

VenueOrganometallics · 2014
Typearticle
Languageen
FieldChemistry
TopicCoordination Chemistry and Organometallics
Canadian institutionsUniversity of Victoria
FundersBasic Energy SciencesNatural Sciences and Engineering Research Council of CanadaU.S. Department of Energy
KeywordsChemistrySteric effectsReactivity (psychology)SubstituentMoietyMedicinal chemistryTerphenylMonomerStereochemistryOrganic chemistry

Abstract

fetched live from OpenAlex

The reactions of the sterically crowded primary alane (Ar Pr i 8 AlH 2 ) 2 (Ar Pr i 8 = C 6 H-2,6(C 6 H 2 -2,4,6-Pr i 3 ) 2 -3,5-Pr i 2 ) with alkynes and alkenes are described. It is shown that hydroalumination of the terminal alkynes HCCSiMe 3 and HCCPh readily occurs under mild conditions via the cis -addition of the Al–H moiety across the CC triple bond with no evidence of hydrogen elimination. Hydroalumination was observed also with a range of terminal olefins, but no reactivity was observed with internal alkenes or alkynes. The relatively high reactivity of (Ar Pr i 8 AlH 2 ) 2 was attributed to the steric crowding of the large terphenyl substituent, which favors dissociation of the alane and increases the availability of the more reactive three-coordinate aluminum site in the monomer. In keeping with this view, studies of the reactions of the three primary alanes (Ar Pr i 8 AlH 2 ) 2, (Ar Pr i 4 AlH 2 ) 2 (Ar Pr i 4 = C 6 H 3 -2,6(C 6 H 3 -2,6-Pr i 2 ) 2 ), and (Ar Me 6 AlH 2 ) 2 (Ar Me 6 = C 6 H 3 -2,6(C 6 H 2 -2,4,6-Me 3 ) 2 ) with alkenes showed that the reaction rates are inversely proportional to the size of the terphenyl substituent, consistent with higher reactivity of the aluminum monomer. The structures of the alkenyl insertion products, Ar Pr i 8 Al(CHCHPh) 2 and Ar Pr i 8 Al(CHCHSiMe 3 ) 2, the alkylated derivative, Ar Pr i 8 Al(CH 2 CH 2 SiMe 3 ) 2, and the precursor aluminates {Li(OEt 2 )H 3 AlAr Pr i 8 ·Li(OEt 2 ) 2 H 3 AlAr Pr i 8 }, (LiH 3 AlAr Pr i 8 ) 2, and alanes (Ar Pr i 8 AlH 2 ) 2, and (Ar Pr i 4 AlH 2 ) 2 were determined by X-ray crystallography.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.031
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.213
Teacher spread0.206 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations26
Published2014
Admission routes2
Has abstractyes

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