Comparison of thromboelastography parameters between different catheter lumen diameters in an uncontrolled haemorrhagic shock model in swine
Bibliographic record
Abstract
Sampling technique is a concern for standardization of thromboelastography (TEG), as it contributes towards preanalytical variation in TEG tracings. The objective of this study was to assess the influence of catheter lumen diameter on TEG parameters with kaolin-activated native blood in a swine haemorrhagic shock model, using standardized sampling techniques. We hypothesized that one or more TEG parameters will differ between venous samples collected from catheters with different diameter lumens. Ten male landrace swine were included in the study. Standard cut-down techniques on both femoral veins were performed and catheterized with a 14-gauge (14G) and a 20-gauge (20G) catheter of the same length. Blood withdrawal times were standardized to 3 s and TEG parameters (R, K, α, maximum amplitude, G and coagulation index) were measured or calculated. Significant differences were detected for R (14G < 20G; P = 0.002), K (14G < 20G; P = 0.026), maximum amplitude (14G > 20G; P = 0.02), G (14G > 20G; P = 0.001) and coagulation index (14G > 20G; P < 0.001). No significant differences were measured for α (P = 0.058). Bias values (method A: 20G; method B: 14G) for R, K, α, maximum amplitude, G and coagulation index were 1.00, 0.14, -1.88, -1.56, -1.39 and -1.07, respectively. Using TEG analysis, kaolin-activated native whole blood samples obtained from 14G catheters are hypercoagulable (clotted faster and stronger clot) compared with samples obtained from 20G catheters. Sampling methodology should be standardized and systematic when comparing TEG parameters.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".