130A Prospective Cohort Study Evaluating the Impact of the Multiplex Respiratory Virus Panel (MRVP) PCR Test on the Clinical Management of Suspected Respiratory Viral Infections in Adult Patients at the McGill University Health Centre (MUHC)
Bibliographic record
Abstract
Background. Rapid diagnostic tests for respiratory viral infections could lead to proper patient management and reduce unnecessary antibiotic use. The objective of this study was to evaluate the impact of the MRVP PCR test on the clinical management of patients with suspected respiratory viral infections. Methods. In a prospective cohort study, data was collected from 176 adult patients from January to February 2014 from the MUHC. Patients with a positive MRVP test were identified by MUHC Infection Prevention and Control. Patients with a negative MRVP test were selected from the same medical floor or department within a one week time frame from a positive MRVP test result. Data was collected prospectively from patients medical charts and retrospectively from electronic medical records to assess the use of antibiotics and antivirals before and after test result. Results. A total of 176 patients were included in the analysis, with 93 patients MRVP test positive and 83 patients MRVP test negative. The patients were allocated to three cohorts: influenza positive, non-influenza positive and test negative. Of the 40 influenza positive patients that received antiviral treatment, 36/40 patients (90%) completed a course of treatment after the test result. Meanwhile, all non-influenza positive patients and 16/20 (80%) test negative patients had empiric antiviral therapy stopped after the test result. Of the 106 patients that received empiric antibiotic treatment, 9/31 (29%) influenza positive patients, 8/18 (44%) non-influenza positive patients and 9/57 (16%) test negative patients had their antibiotic therapy stopped after the test result. Antibiotics were continued in 22/31 (71%), 10/18 (56%) and 47/57 (82%) patients in the influenza positive, non-influenza positive and test negative groups respectively due to culture-positive or radiologically confirmed bacterial infection. Conclusion. Our study indicates that implementation of the MRVP PCR test for diagnosis of respiratory viral infections positively impacted the use of antiviral therapy and lead to antibiotic discontinuation in 25% of cases. Disclosures. All authors: No reported disclosures.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".