The molecular basis of the antidiabetic activity of quercetin in skeletal muscle cells and hepatocytes in culture
Bibliographic record
Abstract
Quercetin is most abundant flavonoid in the human diet. In a previous study, we have reported that quercetin stimulated glucose uptake in cultured C2C12 skeletal muscle through an insulin-independent mechanism involving adenosine monophosphate-activated protein kinase (AMPK). In skeletal muscle, the activation of AMPK increases glucose uptake through the stimulation of glucose transporter GLUT4 translocation to the plasma membrane. In liver, AMPK decreases hepatic glucose production mainly through the downregulation of the key gluconeogenesis enzymes such as phosphoenolpyruvate carboxylase and Glucose 6-phosphate (G6Pase). In the present study, an 18h treatment with quercetin (50µM) was reported to stimulate AMPK and to increase GLUT4 translocation and expression in cultured rat L6 skeletal muscle cells. On the other hand, we reported that quercetin induced hepatic AMPK activation and inhibited G6pase in murine H4IIE hepatocytes. Finally, we have observed that querectin exhibited a mild tendency to increase the activity of glycogen synthase (GS), the rate-limiting enzyme of glycogen synthesis, in the human hepatoma cell line HepG2. Overall, these data demonstrate that quercetin positively influences glucose metabolism in both liver and skeletal muscle, and therefore appear to be a promising therapeutic candidate for the treatment of type 2 diabetes mellitus.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".