EFFECT OF MECHANICAL AND BIOPHYSICAL PROPERTIES OF FIBRIN GEL ON MICROVASCUAL DEVELOPMENT IN A THREE-DIMENSONAL ANGIOGENESIS ASSAY
Bibliographic record
Abstract
This work aims to determine the mechanical and biophysical properties of fibrin gel for the purpose of angiogenesis study and microvascular development in a threedimensional (3D) environment. In the human body system, fibrin gel is known to be an extracellular matrix (ECM) that actively promotes homeostasis during blood vessel formation, wound healing and other inflammation processes. In this study, we first test the effect of fibrin and thrombin composition on mechanical and biophysical properties of the gel. Further in vitro experiments using human umbilical vein endothelial cells (HUVECs) were also conducted to find the optimum fibrinogen/thrombin concentration for the angiogenesis assay using a sandwich fibrin gel system. A fibrinogen/thrombin concentration of 2.0/1.0 results in optimum gel properties for three dimensional angiogenesis assay, which does not appear in other fibrinogen/thrombin concentrations. This sandwiched polymer fiber system has a potential future application for angiogenesis assay in tissue engineering and cardiovascular research.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".