227 Kinome Profiling of Bovine Leukemia Virus-induced Ovine Leukemia: An Approach for Identifying Altered Signaling Pathways and Drugable Targets in Cancer
Bibliographic record
Abstract
Screening new therapeutic agents which specifically inhibit phosphorylation of key cell signaling molecules has become a major focus in cancer research. It is critical, however, that the animal model or cell system used to screen therapeutic agents accurately reflect the biology of the target cancer cells. With the development of species-specific kinome arrays and their application in the Bovine Leukemia Virus (BLV) ovine leukemia model, it was possible to analyze changes in kinase activities associated with B cell transformation. Removal of cancer cells from the host and passage in tissue culture significantly altered phosphorylation patterns that define transformation of this specific cell lineage, suggesting that cell signaling closely reflects responses to the external environment. Thus, high-throughput kinome analysis in this unique large animal model of leukemogenesis provides an opportunity to identify critical phosphorylation events governing onset and progression of malignancy and define whether key cell signaling events that characterize primary cancer cells are accurately reflected in in vivo or in vitro screening models.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".