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Record W2328936155 · doi:10.1177/1470412912455622

The Life of Movement: From Microcinematography to Live-Cell Imaging

2012· article· en· W2328936155 on OpenAlex
Hannah Landecker

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueJournal of Visual Culture · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCell Image Analysis Techniques
Canadian institutionsnot available
FundersUniversity at BuffaloConcordia UniversityNorthwestern University
KeywordsMovement (music)VitalismAnimationCognitive scienceBiologyAestheticsArtVisual artsPsychologyMedicine

Abstract

fetched live from OpenAlex

How do we see life after the century of the gene? This article argues that the post-2000 postgenomic turn was and is a thoroughly visual turn, as well as a theoretical and practical shift away from the central dogma of DNA as master molecule. Live-cell imaging is a rapidly expanding area of scientific visualization of living things whose practice is central in postgenomic biological research and theory. Fluorescent probes enable the visualization of the movement in vivo, over time, of a wide range of vital molecules, for example the movement of motor proteins along the cellular skeleton. Despite its prominence in the life sciences, these moving images have attracted little critical attention outside the scientific community. Comparison with microcinematography of the early 20th century, another time-based medium that also placed the capture of movement at the center of the technique, is used here to frame the emergence of live-cell imaging in the late 20th century and discuss its theoretical significance. This article argues that live-cell imaging was at its origins an animation of a theory of life dominated by the gene. However, focused as it is on the life of proteins, the practice actually facilitated a move away from such dominance, with a rise of a ‘molecular vitalism’: an interest in all cellular molecules as knitted together in a complex moving net in the time and space of the cell. As such, the present moment echoes early 20th-century tensions between the study of structure and function in cellular anatomy versus physiology and puts the focus on molecular movement just as cellular movement was central to earlier practices. Contemporary live-cell imaging does not depict a structure described in a unique moment that explains a life process, but rather visualizes a continuity of movement that constitutes life processes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.018
Threshold uncertainty score0.260

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.278
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it