Pituicytoma of the Neurohypophysis: Analysis of Cell Proliferation Biomarkers
Bibliographic record
Abstract
A 37-year-old man presented with a one year history of diminished libido and a six month history of poor concentration and headaches.No visual field changes were identified.Laboratory testing revealed normal blood hormone levels of total testosterone (10.16 nmol/L, normal 6.7-28.9),growth hormone (0.0 ng/ml, normal<5.0),insulin-like growth factor (132 ng/ml, normal 48-255), thyroid stimulating hormone (2.48 mUI/ml, normal 0.5-6.0),free thyroxin (0.98 ng/dl, normal 0.8-1.8),and cortisol (8.7 mcg/ml, normal 5-25).Blood prolactin levels were mildly elevated (131 ng/ml, normal 0-15), with decreased blood levels of luteinizing hormone (0.09 mUI/ml, normal 2-12), and follicle stimulating hormone (0.0 mUI/ml, normal 1-8).Magnetic resonance imaging (MRI) revealed a circumscribed suprasellar lesion measuring 25x25mm (Figure 1) displacing the pituitary stalk and compressing the optic chiasm and the floor of the third ventricle.There was no evidence of hydrocephalus.Based on MRI a diagnosis of pituicytoma was made.In order to get tissue for morphological studies and to resect subtotally the lesion a right fronto-temporal craniotomy was performed.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".