Sexual Interest and Satisfaction in an Internet Cohort of Patients with Inflammatory Bowel Diseases
Bibliographic record
Abstract
Although GI and other somatic symptoms, concerns about body image, medication side effects, and surgical treatments and ostomies may impair sexual functioning in patients with inflammatory bowel diseases (IBD), few studies have examined this. We sought to evaluate sexual interest and satisfaction in a large cohort of adult patients with IBD and identify clinical and demographic factors associated with these patient-reported outcomes. CCFA Partners is an ongoing internet cohort study of over 12,000 patients with IBD. We invited a randomly selected subset of the cohort to complete a six question supplemental survey regarding sexual interest and satisfaction, and whether IBD symptoms or ostomy (if applicable) affected sexual satisfaction. Measures were developed and validated as part of the NIH Patient Reported Outcome Measurement Information System (PROMIS) initiative. Demographic information, self-reported disease indices [Short Crohn's Disease Activity Index (SCDAI), Simple Clinical Colitis Activity Index (SCCAI), and Manitoba Index], the Short IBD questionnaire (SIBDQ) quality of life index, and additional PROMIS outcomes were also measured. We used descriptive statistics and bivariate comparisons to assess relationships between sexual interest and satisfaction and the other measures. A total of 2581 individuals completed the supplemental survey (32% opted out). Mean age was 42(SD = 14); 71% female. Of 2151 patients who reported active IBD symptoms, 80% indicated that their symptoms affected their sexual satisfaction and 33% indicated their symptoms affected their sexual satisfaction “quite a bit” or “very much”. Of 110 patients with an ostomy, equal numbers reported that their ostomy affected their satisfaction “not at all” or “a little bit” versus “quite a bit” or “very much”. On average, males had higher sexual interest and satisfaction than females (p < 0.001), while there was no difference in sexual interest or satisfaction among those with CD versus UC. Among CD patients, active perirectal disease was associated with lower levels of sexual interest and satisfaction. Sexual interest and satisfaction were both negatively associated with increasing disease activity as measured by SCDAI, SCCAI, and Manitoba Index and positively associated with higher levels of health-related quality of life as measured by SIBDQ (P < 0.001 for all comparisons). Sexual interest and satisfaction were both negatively associated with increasing levels of fatigue, anxiety, and depression. IBD patients are willing to respond to questions regarding their sexual interest and satisfaction, as indicated by the high response rate. IBD, particularly active disease, is associated with impaired sexual functioning. Only about half of patients with ostomies indicated that their ostomies affected sexual satisfaction. Providers should be aware that disease activity can affect sexual function and satisfaction, and counsel or screen appropriate patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".