Preparation of <i>N</i> ‐(Boc)‐Allylglycine Methyl Ester Using a Zinc‐Mediated, Palladium‐Catalyzed Cross‐Coupling Reaction
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract In the context of our research in peptide mimicry, we required an efficient, atom economical route to enantiomerically pure allylglycine analogues. Building on the established precedent of zinc‐mediated, palladium‐catalyzed crosscoupling reactions of commercially available and inexpensive tert ‐butyl ( R )‐1‐(methoxycarbonyl)‐2‐iodoethylcarbamate, this extension employs vinyl bromide to give effective access to allylglycine in enantiomerically pure form on multi‐gram scale. Negishi cross coupling of the alininyl zinc intermediate with vinyl bromide is effectively mediated by Pd 2 (dba) 3 and tri‐( o ‐tolyl)phosphine and has been examined at lower temperature to give the N ‐(Boc)‐allylglycine methyl ester with improved yield.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it