Apoprotein (A) antagonises THE GPIIB/IIIA receptor on collagen and ADP-stimulated human platelets
Why this work is in the frame
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Bibliographic record
Abstract
The nature of the lipoprotein (a) (Lp(a))/agonist-stimulated platelet interaction is unclear. The objective was to determine whether Lp(a) inhibits platelet aggregation by displacing fibrinogen from the platelet GPIIb/IIIa receptor. Platelets were washed in Tyrode's buffer and stimulated using 10 micromolar ADP or 2 micrograms/ml collagen. Lp(a) was isolated from plasma using lectin affinity chromatography followed by ultracentrifugation. Lp(a) inhibited aggregation of collagen- and ADP-stimulated platelets with IC-50's of about 5 mg/dl. Lp(a) inhibited 125I-labeled fibrinogen binding to collagen-stimulated platelets with an IC-50 of less than 5 mg/dl. MAb 3B1, specific for apo(a), restored platelet aggregation to control levels, inhibited 125I-labelled Lp(a) binding, and increased 125I-labelled fibrinogen binding by displacing Lp(a) from the fibrinogen binding site. In conclusion, binding of Lp(a) results in displacement of fibrinogen from its receptor, leading to decreased platelet aggregation. This antagonism suggests a novel role for Lp(a) in modulating fibrinogen binding to the GPIIb/IIIa receptor on collagen- and ADP-stimulated platelets.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it