Encapsulation of Acetyl Ginsenoside Rb<sub>1</sub> within Monodisperse Poly(<scp>dl</scp>-lactide-<i>co</i>-glycolide) Microspheres Using a Microfluidic Device
Bibliographic record
Abstract
6″- O -Acetylginsenoside Rb 1 (ac-Rb 1 ) isolated from North American ginseng was encapsulated within biodegradable poly( dl -lactide- co -glycolide) (PLGA) microspheres. Both a conventional double emulsion and a microfluidic technique were examined for microsphere formation. The ac-Rb 1 encapsulation within PLGA microspheres was characterized by various physicochemical techniques including FTIR, DSC, and XRD. The experimental data showed that the PLGA microspheres produced from the microfluidic technique were uniform with tunable mean diameters from 7 to 59 μm and standard deviations less than 10%. The size was independent of the capillary number and could be tuned by altering the continuous and disperse phase flow rate ratios. Release profiles from the uniform microspheres were investigated, showing controlled release of ac-Rb 1 which followed a Fickian diffusion while retaining potency toward immunosuppressive activity using macrophages in vitro. This study shows that ac-Rb 1 encapsulated PLGA microspheres obtained using the microfluidic approach are promising for the development of next-generation biomedical agents.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".