Intra-septal infusions of excitatory amino acid receptor antagonists have differential effects in two animal models of anxiety
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Bibliographic record
Abstract
Ablation or pharmacological inhibition of the septum produces anxiolytic-like effects in two animal models of anxiety: the elevated plus-maze and the shock-probe burying tests. Overall, these results suggest that the septum normally plays an excitatory role in the control of anxiety-related behaviors. The purpose of the present study was to examine this hypothesis in more detail, by testing the effects of intra-septal infusions of excitatory amino acid (EAA) receptor antagonists on rats' behavior in the shock-probe and plus-maze tests. We found that intra-septal infusions of the non-NMDA (N-methyl-D-aspartic acid) receptor antagonist CNQX (5 microg) suppressed open-arm avoidance in the plus-maze test, and reduced burying behavior in the shock-probe test, without affecting rats' normal avoidance of the shock-probe. In contrast, intra-septal infusions of the NMDA receptor antagonist AP-5 (5 microg) inhibited both shock-probe avoidance and burying behavior, without affecting rats' open-arm avoidance. These dissociations suggest that different EAA receptor types within the septum exert complex but distinct control of different anxiety-related behaviors.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it