Dapagliflozin bei Patienten mit Typ-2-Diabetes und bestehender kardiovaskulärer Erkrankung: Hypotonie und Verträglichkeit in Bezug auf Volumenverlust
Bibliographic record
Abstract
Hintergrund und Ziele: Der selektive SGLT-2-Hemmer Dapagliflozin zur Behandlung von T2DM, erhöht die renale Glukoseausscheidung und führt zu einer leichten osmotischen Diurese. In 2 Studien an unzureichend kontrollierten T2DM-Patienten (HbA1c 7,0 – 10,0%) mit kardiovaskulärer Vorerkrankung wurde Dapagliflozin 10 mg als Zusatztherapie zur üblichen Behandlung mit Plazebo verglichen (Studie 1: NCT01031680, n = 922, Studie 2: NCT01042977, n = 964). Veröffentlichte Ergebnisse zeigten eine stärkere Senkung von HbA1c, Gewicht und systolischem Blutdruck unter Dapagliflozin im Vergleich zu Plazebo. Über 52 Wochen wurde Dapagliflozin zudem gut vertragen.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".