Anti-mycobacterial natural products from Aralia nudicaulis
Bibliographic record
Abstract
Infusions of the rhizomes of Aralia nudicaulis (wild sarsaparilla) are widely used as a traditional medicine to treat respiratory ailments by various First Nation communities in Canada. Methanolic extracts of A. nudicaulis rhizomes were found to have significant antimycobacterial activity when screened in the microplate resazurin assay against Mycobacterium tuberculosis (H37Ra). Bioassay guided fractionation of the rhizome extract resulted in the isolation of two C17 diynes identified as falcarinol and panaxydol by NMR and MS that exhibited MICs of 25.6µM and 36.0µM and IC50s of 15.3µM and 23.5µM against M. tuberculosis (H37Ra), respectively. Additionally, seven endophytic fungi were isolated from the leaves of A. nudicaulis, and extracts of two of these have also exhibited significant anti-mycobacterial activity. The endophyte extracts will be screened using LC-MS to investigate whether falcarinol and panaxydol could be responsible for the anti-mycobacterial activity of both plant and endophyte extracts.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".