Anti-mycobacterial natural products from Aralia nudicaulis
Bibliographic record
Abstract
Infusions of the rhizomes of Aralia nudicaulis (wild sarsaparilla) are widely used as a traditional medicine to treat respiratory ailments by various First Nation communities in Canada. Methanolic extracts of A. nudicaulis rhizomes were found to have significant antimycobacterial activity when screened in the microplate resazurin assay against Mycobacterium tuberculosis (H37Ra). Bioassay guided fractionation of the rhizome extract resulted in the isolation of two C17 diynes identified as falcarinol and panaxydol by NMR and MS that exhibited MICs of 25.6µM and 36.0µM and IC50s of 15.3µM and 23.5µM against M. tuberculosis (H37Ra), respectively. Additionally, seven endophytic fungi were isolated from the leaves of A. nudicaulis, and extracts of two of these have also exhibited significant anti-mycobacterial activity. The endophyte extracts will be screened using LC-MS to investigate whether falcarinol and panaxydol could be responsible for the anti-mycobacterial activity of both plant and endophyte extracts.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".