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Record W2334764564 · doi:10.1177/171516350613900610

RETRACTED: Maternal Codeine is Not Safe for all Breast-Fed Infants

2006· article· en· W2334764564 on OpenAlexvenueno aff
Parvaz Madadi, Gideon Koren, James Cairns, David Chitayat, Andrea Gaedigk, J. Steven Leeder, Ronni Teitelbaum, Tatyana Karaskov

Post-publication record

NatureRetraction
ReasonUnreliable Results and/or Conclusions;
Date11/18/2020 0:00
Flagged by OpenAlex?Yes

Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement; it reports them as false, which reads as “fine”.

Bibliographic record

VenueCanadian Pharmacists Journal / Revue des Pharmaciens du Canada · 2006
Typearticle
Languageen
FieldMedicine
TopicPharmaceutical studies and practices
Canadian institutionsnot available
Fundersnot available
KeywordsCodeineMorphineMedicineOpioidBreast milkLimitingAnesthesiaPharmacologyInternal medicineChemistryReceptor

Abstract

fetched live from OpenAlex

Answer When the mother is an ultra-rapid metabolizer of cytochrome 2D6, she produces much more morphine than most people. Considering limiting codeine administration to no more than a few days and staying aware of potential opioid toxicities are two management points discussed in this article. Codeine is commonly used in the postpartum period for pain associated with episiotomy and caesarean section. As most new mothers initiate breast-feeding, the safety of codeine itself, and its pharmacologically active metabolite, morphine, are of primary concern in breast-fed infants. The American Academy of Pediatrics and major authoritative texts list codeine as compatible with breast-feeding, despite the lack of sufficient published data to support this recommendation. To illustrate the need for further assessment of codeine/morphine transfer into breast milk, we use the case of a full-term, breast-fed infant who died with a picture consistent with morphine overdose. 3 The pharmacogenetic assessment of maternal drug biotransformation was consistent with an enhanced formation of the pharmacologically active opioid, morphine.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.305
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.052
GPT teacher head0.328
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2006
Admission routes1
Has abstractyes

Explore more

Same venueCanadian Pharmacists Journal / Revue des Pharmaciens du CanadaSame topicPharmaceutical studies and practicesFrench-language works237,207