2-Aminopyridinate Titanium Complexes for the Catalytic Hydroamination of Primary Aminoalkenes
Bibliographic record
Abstract
A series of mono(2-aminopyridinato)tris(dimethylamido) titanium complexes, ApTi(NMe 2 ) 3 (where Ap = 2-aminopyridinato), have been prepared via protonolysis, and their reactivity for the hydroamination of primary aminoalkenes has been explored. The Ti complex incorporating N,6-dimesityl-2-aminopyridinate as the supporting ancillary ligand has been shown to yield a catalyst suitable for room-temperature intramolecular hydroamination reactions to give gem -disubstituted five- and six-membered-ring products. The comparison of ApTi(NMe 2 ) 3 with other group 4 catalysts shows that controlling the steric environment at the metal center is the critical determining factor for hydroamination reactivity. The screening of known challenging primary aminoalkene substrates with the most reactive ApTi(NMe 2 ) 3 shows good breadth of reactivity for the reaction. This complex is not able to cyclize secondary aminoalkene substrates, suggesting this reaction proceeds via an intermediate imido [2+2] cycloaddition pathway. An Ap-supported Ti imido complex, which also exhibits hydroamination activity, has been prepared and fully characterized from ApTi(NMe 2 ) 3 and 2,6-dimethylaniline.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".