Insulin resistance and compensation in laminitis-predisposed ponies characterized by the Minimal Model
Bibliographic record
Abstract
Glucose metabolism in Welsh and Dartmoor ponies and ponies disposed to pasture laminitis was characterized using the Minimal Model of glucose and insulin dynamics.Laminitis-disposed ponies were selected based on farm records of previous disease incidence and nonparallel hoof-lines.All ponies were maintained on pasture and in early March each underwent a frequent sampling intravenous (iv) glucose tolerance test which involved a bolus of 300 mg/kg glucose followed 20 min later by an iv bolus of 20 mIU/kg insulin.Sampling began just prior to the glucose dose and continued for 4 h.Glucose and insulin curves were modeled to determine insulin sensitivity, glucose effectiveness, acute insulin response to glucose and disposition index.Ponies with previous incidents of laminitis were less insulin sensitive and demonstrated compensatory insulin hypersecretion compared to ponies not at risk.Management of at-risk ponies to avoid insulin resistance and triggers for insulin secretion could reduce the likelihood of developing clinical laminitis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".