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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K. Speliotes, Cristen J. Willer, S. I. Berndt, Keri L. Monda, Guðmar Þorleifsson, Hana Lango Allen, Cecilia M. Lindgren, Jian Luan, Reedik Mägi, Joshua C. Randall, Sailaja Vedantam, Thomas W. Winkler, Lu Qi, Tsegaselassie Workalemahu, Iris M. Heid, Valgerður Steinthórsdóttir, Heather M. Stringham, Michael N. Weedon, Eleanor Wheeler, Abigail Wood, Teresa Ferreira, Robert J. Weyant, Ayellet V. Segrè, Karol Estrada, Liming Liang, James Nemesh, J. H. Park, Stefan Gustafsson, Tuomas O. Kilpeläinen, Nabila Bouatia‐Naji, Tõnu Esko, M.F. Feitosa, Zoltán Kutalik, Massimo Mangino, Soumya Raychaudhuri, André Scherag, Albert V. Smith, Katja K.H. Aben, Devin Absher, Najaf Amin, Nicole L. Glazer, Michael E. Goddard, Nancy L. Heard‐Costa, Volker Hoesel, Åsa Johansson, Shamika Ketkar, Claudia Lamina, S. Li, Miriam F. Moffatt, Richard H. Myers, N Narisu, John R. B. Perry, Marjolein J. Peters, Michael Preuß, Samuli Ripatti, Fernando Rivadeneira, Camilla H. Sandholt, Laura J. Scott, Nicholas J. Timpson, J. P. Tyrer, S. van Wingerden, Richard M. Watanabe, Charles C. White, Fredrik Wiklund, Cristina Barlassina, Daniel I. Chasman, Matthew N. Cooper, Jan-Hakan Jansson, Robert Lawrence, Niina Pellikka, Inga Prokopenko, Elisabeth Thiering, Helen Alavere, Maria Teresa Sciarrone Alibrandi, Peter Almgren, Alice M. Arnold, Thor Aspelund, Larry D. Atwood, Beverley Balkau, Anthony J. Balmforth, Amanda J. Bennett, Yoav Ben‐Shlomo, Richard N. Bergman, Sven Bergmann, Heike Biebermann, Alexandra I. F. Blakemore, Tanja Boes, Lori L. Bonnycastle, Stefan R. Bornstein, M. J. Brown, Thomas A. Buchanan, Fabio Busonero, Harry Campbell, Francesco P. Cappuccio, Christine Cavalcanti-Proença, Y. D. Chen, C. M. Chen, Peter S. Chines, Lachlan Coin, Martin den Heijer, Shah Ebrahim, Paul Elliott, Roberto Elosúa, G. Eiríksdóttir, Michael R. Erdos, Johan G. Eriksson, Maurizio Facheris, Stephan B. Felix, Pamela Fischer‐Posovszky, Aaron R. Folsom, Nele Friedrich, Nelson B. Freimer, Minjie Fu, Stefan Gaget, PV Gejman, Eco J. C. de Geus, Christian Gieger, Anette P. Gjesing, Anuj Goel, Philippe Goyette, Harald Grallert, Danielle M. Greenawalt, Christopher J. Groves, Vilmundur Guðnason, Anna‐Liisa Hartikainen, Neelam Hassanali, Aki S. Havulinna, Caroline Hayward, Andrew C. Heath, Christian Hengstenberg, Andrew A. Hicks, Anke Hinney, Albert Hofman, Georg Homuth, Jennie Hui, Wilmar Igl, Carlos Iribarren, Bo Isomaa, Kevin B. Jacobs, Ivonne Jarick, Torben Jørgensen, Pekka Jousilahti, Antti Jula, Marika Kaakinen, Eero Kajantie, Lee M. Kaplan, Sekar Kathiresan, JA Kettunen, Leena Kinnunen, Joshua W. Knowles, Ivana Kolčić, Inke R. König, Seppo Koskinen, Péter Kovács, Johanna Kuusisto, Peter Kraft, Kirsti Kvaløy, Olivier Lantieri, Chiara Lanzani, Lenore J. Launer, Terho Lehtimäki, Guillaume Lettre, J. Liu, Marja‐Liisa Lokki, Mattias Lorentzon, Robert Luben, Barbara Ludwig, Paolo Manunta, Diana Marek, Michel Marre, Nicholas G. Martin, Wendy L. McArdle, Barbara McKnight, Thomas Meitinger, Olle Melander, David Meyre, Kristian Midthjell, Grant W. Montgomery, Mario A. Morken, A. P. Morris, Rosanda Mulić, Julius S. Ngwa, Mari Nelis, Matt J. Neville, Dale R. Nyholt, Chris O’Donnell, Stephen O’Rahilly, KL Ong, B. A. Oostra, Guillaume Paré, Markus Perola, Irene Pichler, Kirsi H. Pietiläinen, Carl G. P. Platou, Ozren Polašek, Anneli Pouta, Suzanne Rafelt, Olli Raitakari, Martin Ridderstråle, Winfried Rief, Aimo Ruokonen, Neil R. Robertson, Peter Rzehak, Veikko Salomaa, Alan R. Sanders, Manjinder S. Sandhu, Serena Sanna, J. Saramies, Markku J. Savolainen, Susann Scherag, Sabine Schipf, Heribert Schunkert, Kaisa Silander, Juha Sinisalo, David S. Siscovick, Nicole Soranzo, Ulla Sovio, Jonathan Stephens, Ida Surakka, Amy J. Swift, M. L. Tammesoo, Jean‐Claude Tardif, Maris Teder‐Laving, Tanya M. Teslovich, John R. Thompson, Brian Thomson, Jaakko Tuomilehto, Joyce B. J. van Meurs, G J van Ommen, Vincent Vatin, Jorma Viikari, Sophie Visvikis‐Siest, Véronique Vitart, Carla Ivane Ganz Vogel, Benjamin F. Voight, Lindsay L. Waite, Henri Wallaschofski, G. Bragi Walters, Elisabeth Widén, Susanna Wiegand, SH Wild, Gonneke Willemsen, Daniel R. Witte, Jacqueline C.M. Witteman, Qunyuan Zhang, Lina Zgaga, Andreas Ziegler, Paavo Zitting, John Beilby, I. Sadaf Farooqi, Johannes Hebebrand, Heikki Huikuri, Anthony James, Mika Kähönen, D. F. Levinson, Fabìo Macciardi, Markku S. Nieminen, Claes Ohlsson, Lyle J. Palmer, Paul M. Ridker, Michael Stümvoll, J. Beckmann, Heiner Boeing, Eric Boerwinkle, Dorret I. Boomsma, Mark J. Caulfield, Stephen J. Chanock, Francis S. Collins, L. Adrienne Cupples, George Davey Smith, Jeanette Erdmann, Philippe Froguel, Henrik Grönberg, Ulf Gyllensten, Per Hall, Tamara B. Harris, Andrew T. Hattersley, Richard B. Hayes, Joachim Heinrich, Kristian Hveem, Thomas Illig, Marjo‐Riitta Järvelin, Jaakko Kaprio, Fredrik Karpe, Kay‐Tee Khaw, L. A. Kiemeney, Heiko Krude, Debbie A. Lawlor, Andres Metspalu, Patricia B. Munroe, Willem H. Ouwehand, Oluf Pedersen, Brenda W.J.H. Penninx, Annette Peters, Peter P. Pramstaller, Thomas Quertermous, Thomas Reinehr, Igor Rudan, N. J. Samani, Alan R. Shuldiner, T. D. Spector, J. Tuomilehto, Manuela Uda, André G. Uitterlinden, T. T. Valle, Martin Wabitsch, Gérard Waeber, Nicholas J. Wareham, Hugh Watkins, J. Frank Wilson, Alan F. Wright, M. Carola Zillikens, N. Chatterjee, Steven A. McCarroll, Shaun Purcell, E. E. Schadt, Peter M. Visscher, Themistocles L. Assimes, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Leif Groop, Talin Haritunians, David J. Hunter, R.C. Kaplan, Karen L. Mohlke, Laura‐Maria Peltonen, David Schlessinger, D. P. Strachan, Cornelia M. van Duijn, H-Erich Wichmann, Timothy M. Frayling, U. Thorsteinsdottir, Gonçalo R. Abecasis, Inês Barroso, Michael Boehnke, Kāri Stefánsson, K. E. North, Mark I. McCarthy, J. N. Hirschhorn, Erik Ingelsson, Ruth J. F. Loos
Bibliographic record
VenueCarolina Digital Repository (University of North Carolina at Chapel Hill) · 2010
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsMcMaster UniversityUniversité de Montréal
FundersCambridge Institute for Medical Research, University of CambridgeMedical Research CouncilGoddard Space Flight CenterDiabetesforeningenDiabetestutkimussäätiöH. Lundbeck A/SHjartaverndInstitut de Cardiologie de MontréalFondation Institut de Cardiologie de MontréalPaavo Nurmen SäätiöSvenska KulturfondenSydäntutkimussäätiöGöteborgs LäkaresällskapTechnische Universität DresdenAugustinus FondenVetenskapsrådetStockholms Läns LandstingGlaxoSmithKlineSigne ja Ane Gyllenbergin SäätiöFondation LeenaardsPäivikki ja Sakari Sohlbergin SäätiöNorwegian Institute of Public HealthHelsingin ja Uudenmaan SairaanhoitopiiriKnut och Alice Wallenbergs StiftelseKarolinska InstitutetJuho Vainion SäätiöBritish Heart FoundationBundesministerium für Bildung und ForschungNational Health and Medical Research CouncilOulun YliopistoSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungInstitut National de la Santé et de la Recherche MédicaleAstraZenecaEuropean CommissionFinska LäkaresällskapetYrjö Jahnssonin SäätiöCancerfondenJuvenile Diabetes Research Foundation InternationalDiabetes UKLastentautien TutkimussäätiöNational Institute for Health and Care ResearchWellcome TrustCancer Research UKErasmus Medisch CentrumStiftelsen för Strategisk ForskningHealthwayScottish GovernmentNational Cancer InstituteLundbeckfondenFoundation for Cardiovascular ResearchNational Science FoundationFondation LeducqCentre for Medical Systems BiologyNovo NordiskHjärt-LungfondenAgency for Science, Technology and ResearchJalmari ja Rauha Ahokkaan SäätiöKelaSvenska LäkaresällskapetDeutsche ForschungsgemeinschaftHjerteforeningenBiomedicum Helsinki-säätiöDonald W. Reynolds FoundationChinese Society of Clinical OncologyAmgen
KeywordsGeneticsBody mass indexBiologySingle-nucleotide polymorphismObesitySNPGenetic associationGeneGenotypeEndocrinology
Abstract
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.012
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.012
GPT teacher head0.221
Teacher spread0.210 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
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Citations767
Published2010
Admission routes2
Has abstractyes