Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- Meta-epidemiology (narrow)
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: ObservationalConsensus signal: Observational
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.031
- Threshold uncertainty score
- 1.000
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.210 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ÄÌ1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10 -8 ), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly aSociated loci may provide new insights into human body weight regulation. © 2010 Nature America, Inc. All rights reserved.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Carolina Digital Repository (University of North Carolina at Chapel Hill)
- Topic
- Genetic Associations and Epidemiology
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- McMaster UniversityUniversité de Montréal
- Funders
- Cambridge Institute for Medical Research, University of CambridgeMedical Research CouncilGoddard Space Flight CenterDiabetesforeningenDiabetestutkimussäätiöH. Lundbeck A/SHjartaverndInstitut de Cardiologie de MontréalFondation Institut de Cardiologie de MontréalPaavo Nurmen SäätiöSvenska KulturfondenSydäntutkimussäätiöGöteborgs LäkaresällskapTechnische Universität DresdenAugustinus FondenVetenskapsrådetStockholms Läns LandstingGlaxoSmithKlineSigne ja Ane Gyllenbergin SäätiöFondation LeenaardsPäivikki ja Sakari Sohlbergin SäätiöNorwegian Institute of Public HealthHelsingin ja Uudenmaan SairaanhoitopiiriKnut och Alice Wallenbergs StiftelseKarolinska InstitutetJuho Vainion SäätiöBritish Heart FoundationBundesministerium für Bildung und ForschungNational Health and Medical Research CouncilOulun YliopistoSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungInstitut National de la Santé et de la Recherche MédicaleAstraZenecaEuropean CommissionFinska LäkaresällskapetYrjö Jahnssonin SäätiöCancerfondenJuvenile Diabetes Research Foundation InternationalDiabetes UKLastentautien TutkimussäätiöNational Institute for Health and Care ResearchWellcome TrustCancer Research UKErasmus Medisch CentrumStiftelsen för Strategisk ForskningHealthwayScottish GovernmentNational Cancer InstituteLundbeckfondenFoundation for Cardiovascular ResearchNational Science FoundationFondation LeducqCentre for Medical Systems BiologyNovo NordiskHjärt-LungfondenAgency for Science, Technology and ResearchJalmari ja Rauha Ahokkaan SäätiöKelaSvenska LäkaresällskapetDeutsche ForschungsgemeinschaftHjerteforeningenBiomedicum Helsinki-säätiöDonald W. Reynolds FoundationChinese Society of Clinical OncologyAmgen
- Keywords
- GeneticsBody mass indexBiologySingle-nucleotide polymorphismObesitySNPGenetic associationGeneGenotypeEndocrinology
- Has abstract in OpenAlex
- yes