Tiludronate chez le cheval : Tolérance et effets à court terme sur le métabolisme osseux
Bibliographic record
Abstract
Le but de cette etude etait d'evaluer la tolerance du tiludronate chez le cheval et son effet sur le metabolisme osseux. Cinq chevaux ont recu 1 mg/kg de tiludronate en perfusion lente. Un suivi clinique et biochimique a ete effectue avant traitement et au cours des 24 h qui ont suivi. Deux parametres de la formation osseuse ont ete evalues: l'osteocalcine et l'isoenzyme osseuse de la phosphatase alcaline. Deux marqueurs de la resorption osseuse: CTX-MMP (Carboxy-terminal cross-linked telopeptide of type I collagen generated by matrix metalloproteases) et le CTX-I (Carboxy-terminal cross-linking telopeptide of type I collagen) ont ete mesures. Une legere augmentation non significative de la frequence cardiaque a ete notee a +30 min et a +2h. Une legere hypocalcemie etait presente a +30 min. A +6h, tous les parametres etaient revenus aux valeurs initiales. Aucune modification des parametres renaux et hepatiques n'a ete observee. Aucune variation des marqueurs de la formation osseuse, ni du CTX-MMP n'a ete observee. A +24 h, la concentration en CTX-I a diminue fortement, 72,4 % en moyenne (p = 0,0313). Le tiludronate en perfusion lente est bien tolere chez le cheval sans reaction clinique secondaire significative. II entraine une diminution marquee de la concentration en CTX-I, indiquant un effet inhibiteur de la resorption osseuse.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".