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Record W2340223341 · doi:10.1007/s00439-016-1663-9

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes

2016· article· en· W2340223341 on OpenAlexafffund
Gabriel Cuéllar-Partida, Yi Lu, Suzanne C. Dixon‐Suen, Peter A. Fasching, Alexander Hein, Stefanie Burghaus, Matthias W. Beckmann, Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Adriaan Vanderstichele, Jennifer A. Doherty, Mary Anne Rossing, Jenny Chang‐Claude, Anja Rudolph, Shan Wang‐Gohrke, Marc T. Goodman, Natalia Bogdanova, Thilo Dörk, Matthias Dürst, Peter Hillemanns, Ingo B. Runnebaum, Natalia Antonenkova, Ralf Bützow, Arto Leminen, Heli Nevanlinna, Liisa M. Pelttari, Robert P. Edwards, Joseph L. Kelley, Francesmary Modugno, Kirsten B. Moysich, Roberta B. Ness, Rikki Cannioto, Estrid Høgdall, Claus Høgdall, Allan Jensen, Graham G. Giles, Fiona Bruinsma, Susanne K. Kjær, Michelle A.T. Hildebrandt, Dong Liang, Karen H. Lu, Xifeng Wu, Maria Bisogna, Fanny Dao, Douglas A. Levine, Daniel W. Cramer, Kathryn L. Terry, Shelley S. Tworoger, Meir J. Stampfer, Stacey A. Missmer, Line Bjørge, Helga B. Salvesen, Reidun Kristin Kopperud, Katharina Bischof, Katja K.H. Aben, Lambertus A. Kiemeney, Leon F.A.G. Massuger, Angela Brooks‐Wilson, Sara H. Olson, Valerie McGuire, Joseph H. Rothstein, Weiva Sieh, Alice S. Whittemore, Linda S. Cook, Nhu D. Le, C. Blake Gilks, Jacek Gronwald, Anna Jakubowska, Jan Lubiński, Tomasz Kluz, Honglin Song, Jonathan P. Tyrer, Nicolas Wentzensen, Louise A. Brinton, Britton Trabert, Jolanta Lissowska, Steven A. Narod, Catherine Phelan, Hoda Anton‐Culver, Argyrios Ziogas, Diana Eccles, Ian Campbell, Simon A. Gayther, Aleksandra Gentry‐Maharaj, Usha Menon, Susan J. Ramus, Anna H. Wu, Agnieszka Dansonka‐Mieszkowska, Jolanta Kupryjańczyk, Agnieszka Timorek, Lukasz M. Szafron, Julie M. Cunningham, Brooke L. Fridley, Stacey J. Winham, Elisa V. Bandera, Elizabeth M. Poole, Terry K. Morgan, Ellen L. Goode, Joellen M. Schildkraut, Celeste Leigh Pearce, Andrew Berchuck, Paul D.P. Pharoah, Penelope M. Webb, Georgia Chenevix‐Trench, Harvey A. Risch, Stuart MacGregor

Bibliographic record

VenueHuman Genetics · 2016
Typearticle
Languageen
FieldMedicine
TopicOvarian cancer diagnosis and treatment
Canadian institutionsWomen's College HospitalUniversity of TorontoPublic Health OntarioUniversity of British ColumbiaCanada's Michael Smith Genome Sciences CentreSimon Fraser UniversityBC Cancer Agency
FundersMedical Research and Materiel CommandNational Center for Research ResourcesCanadian Institutes of Health ResearchFrancis Crick InstituteNational Cancer InstituteCancer Research UKCalifornia Breast Cancer Research ProgramNational Center for Advancing Translational SciencesFoundation for the National Institutes of Health
KeywordsBiologySerous fluidHeritabilityGenetic architectureOvarian cancerSingle-nucleotide polymorphismGeneticsCancerGenetic associationClear cellDiseaseOncologyQuantitative trait locusGenotypeInternal medicineGeneCarcinomaMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.043
GPT teacher head0.330
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2016
Admission routes2
Has abstractno

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