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Record W2341059062 · doi:10.1002/ajh.24386

In memoriam: Bernard G. Forget

2016· editorial· en· W2341059062 on OpenAlexfundaboutno aff
Ronald P. McCaffrey, Bertil Glader

Bibliographic record

VenueAmerican Journal of Hematology · 2016
Typeeditorial
Languageen
FieldMedicine
TopicHemoglobinopathies and Related Disorders
Canadian institutionsnot available
FundersNational Institutes of HealthMcGill UniversityMassachusetts General Hospital
KeywordsInternshipMedical schoolMedical laboratoryMedicineFamily medicineMedical educationPathology

Abstract

fetched live from OpenAlex

His early scientific work focused on the purification and characterization of human globin mRNA, and working with Edward Benz, he soon demonstrated the functional properties of their mRNA preparations. Techniques were later developed in partnership with David Houseman to establish a cDNA-mRNA hybridization assay to accurately measure the relative abundance of alpha and beta mRNAs in RNA preparations. This collaboration demonstrated quantitative deficiency of beta-globin mRNA in beta-thalassemia and quantitative deficiency of alpha-globin mRNA in alpha-thalassemia. Later, they demonstrated the deletion of beta-globin gene sequences in the syndrome of hereditary persistence of fetal hemoglobin. The Forget laboratory also carried out detailed mapping, cloning, and characterization of the beta-gene cluster in deletion forms of hereditary persistence of fetal hemoglobin and delta-beta-thalassemia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.025
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: Editorial
Teacher disagreement score0.017
Threshold uncertainty score0.057

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.025
Meta-epidemiology (narrow)0.0020.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0010.000
Science and technology studies0.0020.001
Scholarly communication0.0040.003
Open science0.0020.002
Research integrity0.0060.014
Insufficient payload (model declined to judge)0.0170.021

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.279
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2016
Admission routes2
Has abstractyes

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