Phosphorus and Nitrogen Dual-Doped Hollow Carbon Dot as a Nanocarrier for Doxorubicin Delivery and Biological Imaging
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Innovative phosphorus and nitrogen dual-doped hollow carbon dots (PNHCDs) have been fabricated for anticancer drug delivery and biological imaging. The functional groups of PNHCDs are introduced by simply mixing glucose, 1,2-ethylenediamine, and concentrated phosphoric acid. This is an automatic method without external heat treatment to rapidly produce large quantities of PNHCDs, which avoid high temperature, complicated operations, and long reaction times. The as-prepared PNHCDs possess small particle size, hollow structure, and abundant phosphate/hydroxyl/pyridinic/pyrrolic-like N groups, endowing PNHCDs with fluorescent properties, improving the accuracy of PNHCDs as an optical monitoring code both in vitro and in vivo. The investigation of PNHCDs as an anticancer drug nanocarrier for doxorubicin (DOX) indicates a better antitumor efficacy than free DOX owing to its enhanced nuclear delivery in vitro and tumor accumulation in vivo, which results in highly effective tumor growth inhibition and improved targeted therapy for cancer in clinical medicine.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it