Neurocognition and quality-of-life in brain metastasis patients who have been irradiated focally or comprehensively
Bibliographic record
Abstract
As patients are living longer with metastatic disease, preservation of quality of life (QoL) becomes an important goal as treatment shifts from curative to palliative intent. Stereotactic radiosurgery (SRS) has emerged as an alternative to whole brain radiation therapy (WBRT) in the treatment of brain metastases. The decision between SRS and WBRT balances the competing risks of neurocognitive side effects, which are higher in patients treated with WBRT, with risks of intracranial recurrence, which are higher in patients treated with SRS alone. Within this review, we summarize the types of neurocognitive and QoL tests used in clinical trials, and the randomized control trials (RCTs) that evaluated the impact of radiation therapy (RT) on neurocognition and QoL.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".