Different Doses and Routes of Administration of Methimazole Affect Thyroid Status in Methimazole-Induced Hypothyroidism in Rats
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Bibliographic record
Abstract
OBJECTIVE: It is agreed that methimazole (MMI) can be administered to induce hypothyroidism. However, there are conflicting data about its effect on thyroid function and development in rats through different administrations. In the present study, we established and compared differences of the rat hypothyroid model induced by MMI added to drinking water or given through an intragastric tube. METHODS: Sixty-four male Wistar rats were randomly divided into seven groups. Methimazole was added to the drinking water (0.025%, 0.04% or 0.1% wt/vol), or through intragastric gavage (5 mg/100 g body weight (bw) or 8 mg/100 g bw) one time each day for 21 days. The rats were weighed every seven days. Blood samples were taken in order to detect the concentrations of serum triiodothyronine (T3), thyroxine (T4) and thyrotropin (TSH) at the end of the experiments. RESULTS: Our results indicate that the effect of methimazole on a rat's thyroid function and body weight is similar in both the group given 0.1% concentration in drinking water and the group which received 8 mg/100 g bw once daily through the intragastric tube. Also, a similar effect was observed in the 0.025%, 0.04% and 5 mg/100 g bw groups. CONCLUSION: These findings suggest that a relationship between the concentration of MMI by oral administration and the dose of it through intragastric administration could exist, and may contribute to inducing hypothyroidism in rats.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it