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Record W2342324619 · doi:10.1093/aje/kwv235

The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium

2015· article· en· W2342324619 on OpenAlexafffund
E. Susan Amirian, Georgina Armstrong, Renke Zhou, Ching C. Lau, Elizabeth B. Claus, Jill S. Barnholtz‐Sloan, Dora Il’yasova, Joellen Schildkraut, Francis Ali‐Osman, Siegal Sadetzki, Christoffer Johansen, Richard S. Houlston, Robert B. Jenkins, Daniel H. Lachance, Sara H. Olson, Jonine L. Bernstein, Ryan Merrell, Margaret Wrensch, Faith G. Davis, Rose Lai, Sanjay Shete, Christopher I. Amos, Michael E. Scheurer, Kenneth Aldape, Irina Alafuzoff, Thomas Brännström, Helle Broholm, Peter Collins, Caterina Giannini, Marc K. Rosenblum, Tarık Tihan, Beatrice Melin, Melissa L. Bondy

Bibliographic record

VenueAmerican Journal of Epidemiology · 2015
Typearticle
Languageen
FieldMedicine
TopicGlioma Diagnosis and Treatment
Canadian institutionsUniversity of TorontoUniversity of Alberta
FundersNational Cancer InstituteMedicinska fakulteten, Umeå UniversitetAudrey and Theodor Geisel School of Medicine at DartmouthUniversity of California, San FranciscoUniversity of Texas MD Anderson Cancer CenterSchool of Medicine, Case Western Reserve UniversityNational Institutes of HealthSackler Faculty of Medicine, Tel-Aviv UniversityNorris Cotton Cancer CenterMemorial Sloan-Kettering Cancer CenterUppsala UniversitetRigshospitaletDan L. Duncan Cancer Center, Baylor College of MedicineUmeå UniversitetUniversity of AlbertaNorthShore University HealthSystemCase Comprehensive Cancer Center, Case Western Reserve UniversityGeorgia State UniversityDartmouth CollegeU.S. Public Health ServiceBaylor College of MedicineSchool of Medicine, University of California, San FranciscoUniversity of Southern CaliforniaYale UniversityUniversity of TorontoBrigham and Women's HospitalCase Western Reserve University
KeywordsGliomaEpidemiologyMedicineOncologyPathologyCancer research

Abstract

fetched live from OpenAlex

Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity of tumor subtypes, and retrospective exposure assessment. Here, we briefly describe the Glioma International Case-Control (GICC) Study (recruitment, 2010-2013), a study being conducted by the Genetic Epidemiology of Glioma International Consortium that integrates data from multiple data collection sites, uses a common protocol and questionnaire, and includes biospecimen collection. To our knowledge, the GICC Study is the largest glioma study to date that includes collection of blood samples, which will allow for genetic analysis and interrogation of gene-environment interactions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.008
metaresearch head score (Gemma)0.034
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.091
Threshold uncertainty score0.975

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0080.034
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.059
GPT teacher head0.373
Teacher spread0.314 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations63
Published2015
Admission routes2
Has abstractyes

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