Adenocarcinoma (AC) small intestine (SI). Review of prognostic factors and treatment outcomes
Bibliographic record
Abstract
15117 Background: AC of SI is a rare disease. Review of 123 cases was done for prognostic factors and treatment outcomes. Methods: Total of 123 cases identified using Saskatchewan Cancer Agency registry. A data collection sheet was generated and chart review was performed. Cause specific survival (CSS) was based on primary cause of death from AC of SI. Survival was calculated using Kaplan Meyer survival curves. P values were calculated using log rank test. Results: CSS of the whole group was 565 days. CSS with no metastatic disease (MD) at presentation was 792 days. 30 patients presented with MD. Patient with MD at presentation who did not receive chemotherapy had a CSS of 83 days. 13 out of 30 patients with MD received 5 flurouracil based chemotherapy. CSS of patients with MD who received chemotherapy was 363 days compared to 83 days who did not receive chemotherapy (p. 0.0036). 11 patients with stage I to III received adjuvant fluropyramidine based chemotherapy. CSS of patients who did not receive adjuvant chemotherapy was 617 days and 52% of patients who received chemotherapy had a survival of 1307 days. There were no further events till 3788 days. CSS for grade 1 tumor was 37.5%, for grade 2 it was 28.9% and 26.4% for Grade 3 tumors. (P value 0.571). 5 year CSS was 15.8% for patients with duodenal involvement 10% for patients with ileal disease and 23.5% for patients with jejunal involvement. (P value 0.415). 5 year CSS with T4 lesions was 18.6% compared to 35% for patients with T3 lesions. (P value 0.077). Patient with node positive disease had 5 years CSS of 11.6% compared to 44.1% with node negative disease. (P value 0.004). Median age at diagnosis was 71 years. CSS of patients with age more than 71 years was 15.3% compared to 19% for less than 71 years of age. (P value .078). Conclusions: Patients who received 5 flurouracil based chemotherapy for MD and in adjuvant setting seems to have better survival outcome. However this may be related to selection bias. Nodal Involvement was associated with poor outcome. Factors as grade of tumor, T stage, age and site of disease involvement were not found to have independent prognostic significance. No significant financial relationships to disclose.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.003 | 0.005 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".