Conventional Hemodialysis is Associated with Greater Bone Loss than Nocturnal Hemodialysis: A Retrospective Observational Study of a Convenience Cohort
Bibliographic record
Abstract
BACKGROUND: Compared with the general population, end-stage renal disease patients are at increased risk for bone loss and fractures. Nocturnal hemodialysis offers superior calcium-phosphate control and improved uremic clearance compared with conventional hemodialysis. Rates of bone loss by type of hemodialysis are unknown. OBJECTIVES: This study aims to determine whether there are differences in bone loss between frequent nocturnal hemodialysis and conventional hemodialysis. DESIGN: This is a retrospective observational study. SETTING: Participants were selected from two teaching hospitals in downtown Toronto. PARTICIPANTS: The study included 88 participants on dialysis for at least 6 months (52 patients on conventional hemodialysis and 36 patients converted from conventional hemodialysis to nocturnal hemodialysis). Patients on peritoneal dialysis and with previous renal transplants were excluded. MEASUREMENTS: We obtained demographic variables and biochemical data by a chart review. We examined changes in bone mineral density at the hip (femoral neck, total hip) and spine (L1 to L4) measured at baseline and about 1 year in the two groups. METHODS: We used Student's t test for evaluation of between-group mean differences in demographic and biochemical parameters. We used linear regression models adjusted for baseline age, weight, dialysis vintage, markers of mineral metabolism (serum phosphate, serum calcium, and parathyroid hormone), and baseline bone mineral density at the femoral neck, total hip, and lumbar spine to determine the annualized percent change by hemodialysis type. RESULTS: Conventional hemodialysis subjects were older than nocturnal hemodialysis subjects (66 ± 9 vs 43 ± 10 years; p < 0.0001) with no significant differences in weight, dialysis vintage, serum phosphate, or parathyroid hormone between the two groups at baseline. In a period over 1 year, conventional hemodialysis compared to nocturnal hemodialysis subjects had significantly greater bone mineral density losses at all sites (1.6 % loss at the lumbar spine (95 % confidence interval (CI) 0.2-3.1), 1.3 % loss at the femoral neck (95 % CI 0.1-2.5), and 1.1 % loss at the total hip (95 % CI 0.1-2.6). LIMITATIONS: Some limitations to this study are the lack of medication administration history, short duration (~1 year), and small sample sizes. CONCLUSIONS: This is the first study comparing bone density between hemodialysis modalities. Our study demonstrates that bone loss is less in nocturnal hemodialysis compared to that in conventional hemodialysis which may result in less fractures. Larger observational studies are ultimately needed to confirm preliminary findings from our study.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".