Limiting the Testing of Aspartate Aminotransferase: Using the Proper Upper Limit of the Reference Interval of Alanine AminotransferaseThe Authors’ Reply
Bibliographic record
Abstract
Limiting the Testing of AST: A Diagnostically Nonspecific Enzyme," in which the authors claimed that only aspartate aminotransferase (AST) could be measured when alanine aminotransferase (ALT) exceeds a predetermined limit, and so a substantial health care budget could be saved. That is a great idea. However, some questions need to be clarified about this article. According to the description in the Materials and Methods section, the objects tested were in the city of Edmonton, which is the capital of Alberta, Canada. However, the upper limit of the reference interval (ULRI) of ALT 1,2 (30 U/L) used in the article came from Italy. Our questions are as follows: (1) is the ULRI used in this article suitable to evaluate the objects? and (2) why did the authors not use the reference intervals of ALT 3 that have been generated from the local area? In addition, we found that only the reference intervals of AST were cited in the article but not that of ALT.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.012 | 0.025 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.005 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.006 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".