EFFECTS OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE ON THE PHOSPHORYLATION OF PROTEIN KINASE B (PKB/AKT) AND ITS CONTRIBUTION TO PANCREATIC BETA-CELL SURVIVAL.
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is a major regulator of postprandial insulin secretion in mammals. Recent studies have suggested that GIP is a potent stimulus for protein kinase activation of the PI3kinase/PKB cascade. We hypothesized that GIP could regulate cell fate and sought to investigate the underlying mechanisms involved in GIP stimulation of cell survival using the β(INS-1) cell line and human pancreatic islets. In response to GIP stimulation, β(INS-1) cell PKB was phosphorylated at the two known phosphosites, threonine (Thr) 308 and serine (Ser) 473, with maximal levels reached after 60 minutes (n = 3, p
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it