The influence of PTD-OD-HA fusion proteins on apoptosis of bcr/abl positive cell lines
Bibliographic record
Abstract
Objective:To study the influence of protein transduction domain(PTD)-oligomerization domain(OD)-HA fusion proteins on apoptosis of bcr/abl-positive cell lines.Methods:bcr/abl-positive cells were treated with PTD-OD-HA protein.The apoptoses of the cells were detected by flow cytometry(FCM),DNA ladder and transmission electron microscopy(TEM),and the levels of apoptosis-related genes bax and bcl-2 were detected by RT-PCR and Western blotting.Results:FCM examination demonstrated that PTD-OD-HA protein induced the apoptosis of bcr/abl-positive cells;DNA ladder showed that the classic DNA ladders appeared in BaF3-P210 and K562 cells after 48 h treatment with PTD-OD-HA proteins;the apoptoses of BaF3-P210 cells were observed by TEM;the levels of bax in mRNA and protein increased in BaF3-P210 and K562 cells,and bcl-2 decreased.Conclusion:PTD-OD-HA proteins specifically induced the apoptosis of bcr/abl positive cells.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".