Bibliographic record
Abstract
AIM To investigate the anxiolytic effect and mechanism of action of the indo derivative I 20 ,a ligand of the peripheral benzodiazepine receptor. METHODS The anxiolytic effect was tested in the elevated plus maze and the light dark box. The content of progesterone in the rat plasma after injection of various doses of drugs in different time points was measured by radio immunoassay . RESULTS Compound I 20 (1 mg·kg -1 , ip) exhibited the anxiolytic effect in mice by increasing the time percentage into the open arms in the elevated plus maze and the number of transitions in the light dark box. I 20 failed to affect the locomotor activity in mice in the test dose(20 mg·kg -1 ,ip),suggesting I 20 did not induce sedation in the anxiolytic doses. I 20 induced a dose dependent and time dependent increase in the concentrations of the neurosteroid (progesterone) in the rat plasma. CONCLUSION The indole derivative I 20 may produce anxiolytic like effect by interacting with the PBR receptor, promoting the biosynthesis of neurosteroid progesterone and modulating the GABA A function indirectly.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.007 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".